教育和工作经历

2024.07-至今， 永利欢乐娱人城， 药物化学与分子工程， 副教授

2019.12-2024.06， 永利欢乐娱人城， 药物化学与分子工程， 讲师

2017.11-2019.11， 哈佛医学院/麻省总医院， 放射性药物化学，博士后（合作导师：Steven H. Liang）

2012.09-2017.06， 永利欢乐娱人城，无机化学，博士（导师：刘伯里先生）

2008.08-2012.06， 兰州大学核科学与技术学院，  应用化学(放射化学基地班)，学士

招生信息

每年招收至少1名硕士生。 欢迎热爱科研、工作认真、积极向上的同学加入。

研究领域

       课题组致力于开发用于正电子发射断层扫描(positron emission tomography, PET)成像和放射性配体治疗(radioligand therapy, RLT)的新型放射性药物，为临床问题的解决提供“放射化学工具”。研究兴趣主要是：

1）Small-molecule PET ligands for brain imaging to provide solutions for Alzheimer’s disease;

2）Radioligands (including small molecules and peptides) for tumour imaging and radioligand therapy.

代表性成果

(1) Wanqing Li, Xiaojun Zhang, Jie Ma, Jingyin Zhou, Xuan Di, Donglan Huang, Kaixiang Zhou, Jinming Zhang,^* Lu Wang,^* Hualong Fu,^* and Mengchao Cui, Preclinical evaluation of dihydropyrazole-cored positron emission tomography (PET) ligands for imaging of receptor-interacting serine/threonine protein kinase 1 (RIPK1) in the brain, J. Med. Chem. 2024, 67, 18, 16403–16415.

(2) Wanqing Li, Xiaojun Zhang, Jingyin Zhou, Xuan Di, Donglan Huang, Jie Ma, Kaixiang Zhou, Jinming Zhang,^* Lu Wang,^* Hualong Fu,^* and Mengchao Cui, Structure-based discovery of a 4,5-dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain, Eur. J. Med. Chem. 2024, 279, 116803.

(3) Wanqing Li,^# Yuqing Qiao,^# Jiahui Chen, Yinlong Li, Xiaoyu Du, Steven H. Liang, Hualong Fu*, Visualizing reactive astrocytes: Positron emission tomography imaging ligands for imidazoline-2 binding sites, VIEW, 2023, 20230037.

(4) Hualong Fu, Jian Rong, Zhen Chen, Jingyin Zhou, Thomas Collier, and Steven H. Liang*, Positron emission tomography (PET) imaging tracers for serotonin receptors, J. Med. Chem. 2022, 65, 10755−10808.

(5) Nan Yue, ^# Hualong Fu,*^,# Yimin Chen, Xi Gao, Jiapei Dai, and Mengchao Cui, Rational design of molecular rotor-based fluorescent probes with bi-aromatic rings for efficient in vivo detection of amyloid-β plaques in Alzheimer’s disease, Eur. J. Med. Chem. 2022, 243, 114715.

(6) Qi Zeng, Yimin Chen, Yingying Yan, Rong Wan, Yanjing Li, Hualong Fu,* Yu Liu, Sen Liu,* Xiao-Xin Yan, and Mengchao Cui*, D-pi-A-based trisubstituted alkenes as environmentally sensitive fluorescent probes to detect lewy pathologies, Anal. Chem. 2022, 94, 15261−15269.

(7) Hualong Fu, Zhen Chen, Lee Josephson, Zijing Li,* and Steven H. Liang*, Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N‐Methyl‐D‐aspartate (NMDA), α‐Amino-3- hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors, J. Med. Chem. 2019, 62, 403−419.

(8) Hualong Fu; Weiting Tang; Zhen Chen; Vasily V. Belov; Genwei Zhang; Tuo Shao; Xiaofei Zhang; Qingzhen Yu; Jian Rong; Xiaoyun Deng; Wei Han; Scott J. Myers; Pilar Giffenig; Lu Wang; Lee Josephson; Yihan Shao; April T. Davenport; James B. Daunais; Mikhail Papisov; Hongjie Yuan; Zijing Li^*; Stephen F. Traynelis^*; Steven H. Liang^* Synthesis and preliminary evaluations of a triazole-cored antagonist as a PET imaging probe ([¹⁸F]N2B-0518) for GluN2B subunit in the brain. ACS Chem. Neurosci. 2019, 10, 2263−2275.

(9) 付化龙，周婧茵，一类靶向于CSF1R激酶的苯基酰胺类化合物及其应用，授权公告 号：CN 118027009 B. 授权时间：2024.07.12