讲授课程

基础有机化学（双语）（专业基础课）；生活化学实验及原理（优质通识课）；

有机化学的魅力（新生研讨课）；化学前沿与挑战（博士学位基础课）；

合成化学（硕士生专业基础课）

研究兴趣

1）化学生物学：有机小分子非病毒基因载体和荧光探针的设计合成及性能研究；药物缓释体系的设计及性能研究；生物活性小分子荧光探针设计合成及性能研究。

2）超分子化学：分子拉链的设计合成及肽的折叠组装研究；刚性大环的设计合成及其可控自组装。

3）应用开发：工业废水处理，药物中间体研制。

代表性论文

(1) Wu, C.-Y.; Su, S.; Zhang, X.; Liu, R.*; Gong, B.; Lu, Z.-L.*, Covalently linked hexakis(m-phenylene ethynylene) macrocycles as molecular nanotubes. Angew. Chem., Int. Ed. 2023, 62, e202303242.

(2) Sun, X.-Y.; Liang, Y.-X.; Gao, Y.-N.; Zhang, X.; Liu, R.; Tang, Q.*; Lu, Z.-L.*; Liu, Y.*, [12]aneN3-Modified camptothecin and PEGylated AIEgens co-assembly into core-shell nanoparticles with ROS/NTR dual-response for enhanced cancer therapy. J. Mater. Chem. B. 2023, 11, 8943-8955.

(3) 王倩, 刘旭英, 唐芳, 卢忠林*. 基于大环多胺[12]aneN₃多功能非病毒基因载体的合成及性质. 科学通报, 2022, 67, 2298–2317.

(4) Liu, X.-Y.; Zhang, X.; Yang, J.-B.; Wu, C.-Y.; Wang, Q.; Lu, Z.-L.; Tang, Q., Multifunctional amphiphilic peptide dendrimer as nonviral gene vectors for effective cancer therapy via combined gene/photodynamic therapies. Colloids and Surfaces, B: Biointerfaces 2022, 217, 112651.

(5) Liu, X.-Y.; Yang, J.-B.; Wu, C.-Y.; Tang, Q.; Lu, Z.-L.*; Lin, L.*; [12]aneN₃- Conjugated AIEgens with two-photon imaging properties for synergistic gene/photodynamic therapy in vitro and in vivo. J. Mater. Chem. B. 2022, 10, 945-957.

(6) Liang, Y.-X.; Sun, X.-Y.; Xu, D.-Z.; Huang, J.-R.; Tang Q.; Lu, Z.-L.*; Liu, R.*; H₂O₂-Responsive amphiphilic polymer with aggregation-induced emission (AIE) for DOX delivery and tumor therapy. Biorg. Chem. 2022, 119, 105559.

(7) Liu, M.-X.; Liu, X.-Y.; Liu, J.-Y.; Tang, J.-T.; Shi, K.; Mao, J.; Lu, Z.-L.*; Qiao, H.-J.*; He, L.* Di[12]aneN3-functionalized green fluorescent protein chromophore for GFP luminescence simulation and efficient gene transfection in vitro and in vivo. ACS Appl. Bio. Mater. 2021, 4(9), 7111-7112.

(8) Ma, L.-L.; Tang, Q.; Liu, M.-X.; Liu, X.-Y.; Liu, J.-Y.; Lu, Z.-L.; Gao, Y.-G.; Wang, R. [12]aneN3-Based Gemini-Type Amphiphiles with Two-Photon Absorption Properties for Enhanced Nonviral Gene Delivery and Bioimaging. ACS Appl. Mater. Interf. 2020, 12, 40094-40107.

(9) Wang, Q.-H; Zhong, Y.-L.; Miller, D. P.; Lu, X.-L.; Tang, Q.; Lu, Z. -L.; Zurek, E.; Gong, B.*; Liu, R.* Self-assembly and molecular recognition in water: Tubular stacking and guest-templated discrete assembly of water-soluble, shape- persistent macrocycles. J. Am. Chem. Soc., 2020, 142，2915-2924.

(10) Tang, Q.; Zhong, Y. -L.; Miller, D. P.; Liu, R.; Zurek, E.; Lu, Z-L.*; Gong, B.* Reverse turn foldamers: An expanded β-turn motif reinforced by double hydrogen bonds. Org. Lett., 2020, 22， 1003-1007.

(11) Shi, Y.-D.; Tang, Q.; Jiang, Y.-F.; Pei, Q.; Tan, H.-W.; Lu, Z.-L.*; Gong, B.*, Effective formation of stable and versatile double-stranded β-sheets templated by a hydrogen-bonded duplex. Chem. Comm.  2018, 54 (30), 3719-3722.

(12) Li Z.-H.; Tan, Z.-L.; Ding. A-X.; Gong, B.; Lu, Z.-L.*; He L.,* Nitric oxide-responsive vesicles as a drug delivery system. Chem. Commun., 2017, 53, 3535-38.

(13) Wang, Q.-H.; Yu, L.-J.; Liu, Y.; Lin, L.; Lu, R.-G.; Zhu, J.-P.; He, L.*; Lu, Z.-L.*， Methods for the detection and determination of nitrite and nitrate: A review. Talanta, 2017, 165, 709-20.

(14) Wei, X.; Zhang, G.; Shen, Y.; Zhong, Y.; Liu, R.; Yang, N.; Al-mkhaizim, F. Y.; Kline, M. A.; He, L.; Li, M.; Lu, Z.-L.*; Shao, Z.*; Gong, B.*, Persistent organic nanopores amenable to structural and functional tuning. J. Am. Chem. Soc. 2016, 138, 2749-2754.

(15) Gao Y. G., Shi Y. D., Zhang Y., Hu J.,  Lu Z. L.,* He L.* A naphthalimide-based [12]aneN₃ compound as an effective and real-time fluorescence tracking nonvival gene vector. Chem. Commun., 2015, 51, 16695-16698.

(16) Chen, H. L., Guo Z. F., Lu Z. L.* Controlling ion-sensing specificity of N-amidothioureas: From anion-selective sensors to highly Zn²⁺-selective sensors by tuning electronic effects. Org. Lett. 2012, 14, 5070-5073.

(17) Bunn S. E., Liu C. T., Lu Z. L., Neverov A. A., Brown R. S. Dinuclear Zn(II) complex catalyzed cyclization of a series of 2-hydroxypropyl aryl phosphate RNA models. Progressive change in mechanism from rate-limiting P-O bond cleavage to substrate binding J. Am. Chem. Soc., 2007, 129, 11642-11652.

(18) Lu，Z. L.; Liu, T.; Neverov, A. A.; Brown, R. S.; Rapid three-step cleavage of RNA and DNA model systems promoted by a dinuclear Cu(II)-complex in Methanol. Energetic origins of the catalytic efficacy,  J. Am. Chem., Soc., 2007, 129, 11642-11652.

(19) Neverov, A. A.; Lu, Z. L.; Maxwell, C. I.; Mohamed, M. F.; White, C. J.; Tsang, J. S. W.; Brown, R. S.; Combination of a dinuclear Zn²⁺ complex and a medium effect exerts a 10¹²-fold rate enhancement of cleavage of an RNA and DNA model system.     J. Am. Chem. Soc.  2006,  128,  16398-16405.

(20) Novak, F., Speiser B., Lindner E., Lu Z. L., Mayer A., A chemically modified platinium electrod as a bidental diamine ligand forming well defined, immobilized bis(1-P-ether-phosphine)(diamine)ruthenium(II) complexes, Angew. Chem Int. Eng., 2004, 2256.

(21) Lu, Z. L.; Lindner Ekkehard; Mayer Hermann A. Applications of sol-gel processed interphase catalysts. Chem. Rev. 2002, 102, 3543-3578.

(22) Lu, Z. L.; Duan, C. Y.; Tian, Y. P.; You, X. Z.; Huang, X. Y. Synthesis, characterization, and crystal structure of a novel copper(II) complex with an asymmetric coordinated 2,2'-bipyridine derivative: A model for the associative complex in the ligand-substitution reactions of [Cu(Tren)L]2+ Inorg. Chem. 1996, 35, 2253-2258.