讲授课程

波谱原理，有机化学实验

研究兴趣

不对称催化合成

代表性论文

1. Yan, Q.; Shen, X.; Zi, G.; Hou, G.* Rh-Catalyzed Asymmetric Hydrogenation of α,β- and β,β-Disubstituted Unsaturated Boronate Esters. Chem. Eur. J. 2020, 26, 5961 – 5964.

2. Yan, Q.; Xiao, G.; Wang, Y.; Zi, G.; Zhang, Z.; Hou, G.* Highly Efficient Enantioselective Synthesis of Chiral Sulfones by Rh-Catalyzed Asymmetric Hydrogenation. J. Am. Chem. Soc. 2019, 141, 1749-1756.

3. Han, S.; Shen, X.; Kong, D.; Zi, G.; Hou, G.*; Zhang, J.* Cu-Catalyzed Asymmetric Hydroboration of Naphthylallylic Compounds for Enantioselective Synthesis of Chiral Boronates. J. Org. Chem. 2019, 84, 4318-4329.

4. Li, X.; Wang, C.; Song, J.; Yang, Z.; Zi, G.; Hou, G.* Copper-Catalyzed Asymmetric Hydroboration of 2H-Chromenes Using a Chiral Diphosphine Ligand. J. Org. Chem. 2019, 84, 8638-8645.

5. Kong, D.; Han, S.; Zi, G.; Hou, G.*; Zhang, J.* Enantioselective Synthesis of Boryl Tetrahydroquinolines via Cu-Catalyzed Hydroboration. J. Org. Chem. 2018, 83, 1924-1932.

6. Kong, D.; Han, S.; Wang, R.; Li, M.; Zi, G.; Hou, G.* Kinetic Resolution of Racemic 2-Substituted 1,2-Dihydroquinolines via Asymmetric Cu-Catalyzed Borylation. Chem. Sci. 2017, 8, 4558-4564 .

7. Zhang, Y.; Yan, Q.; Zi, G.;Hou, G.* Enantioselective Direct Synthesis of Free Cyclic Amines via Intramolecular Reductive Amination. Org. Lett. 2017, 19, 4215-4218.

8. Li, M.; Kong, D.; Zi, G.; Hou, G.* Rh-Catalyzed Asymmetric Hydrogenation of 1,2-Dicyanoalkenes. J. Org. Chem. 2017, 82, 680-687.

9. Kong, D.; Li, M.; Wang, R.; Zi, G.; Hou, G.* Asymmetric Hydrogenation of β-Aryloxy/Alkoxy Cinnamic Nitriles and Esters. Org. Lett. 2016, 18, 4916-4919. (SYNFACTS, Highlight)

10. Kong, D.; Li, M.; Zi, G.; Hou, G.*; He, Y.* Enantioselective Hydrogenation of Diarylmethanimines for Synthesis of Chiral Diarylmethylamines. J. Org. Chem. 2016, 81, 6640-6648.

11. Yan, Q.; Kong, D.; Zhao, W.; Zi, G.; Hou, G.* Enantioselective Hydrogenation of β,β-Disubstituted Unsaturated Carboxylic Acids under Base-Free Conditions. J. Org. Chem. 2016, 81, 2070-2077.

12. Yan, Q.; Kong, D.; Li, M.; Hou, G.*; Zi, G. Highly Efficient Rh-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Nitriles. J. Am. Chem. Soc. 2015, 137, 10177-10181.

13. Liu, M.; Kong, D.; Li, M.; Zi, G.; Hou, G.* Iridium-Catalyzed Enantioselective Hydrogenation of β,β-Disubstituted Nitroalkenes. Adv. Synth. Catal. 2015, 357, 3875-3879.

14. Yan, Q.; Liu, M.; Kong, D.; Zi, G.; Hou, G.* Highly Efficient Iridium-Catalyzed Asymmetric Hydrogenation of β-Acylamino Nitroolefins. Chem. Commun. 2014, 50, 12870-12872.

15. Hou, G.-H.; Li, W.; Ma, M.-F.; Zhang, X.; Zhang X.* Highly Efficient Iridium-Catalyzed Asymmetric Hydrogenation of Unprotected b-Enamine esters. J. Am. Chem. Soc. 2010, 132, 12844-12846. (SYNFACTS, Highlight).

16. Hou, G.-H.; Tao, R.; Sun, Y.-K; Zhang X.*; Gosselin, F. Iridium-Monodentate Phosphoramidite-Catalyzed Asymmetric Hydrogenation of Substituted Benzophenone N-H Imines. J. Am. Chem. Soc. 2010, 132, 2124-2125.

17. Hou, G.-H.; Gosselin, F.; Li, W.; McWilliams, J.; Sun, Y.-K; Weisel, M.; O’Shea, P.; Chen, C.-Y.; Davies, I.; Zhang, X.* Enantioselective Hydrogenation of N-H Imines. J. Am. Chem. Soc. 2009, 131, 9882-9883. (SYNFACTS, Highlight).

18. Hou, G.-H.; Xie, J.-H; Yan, P.-C.; Zhou, Q.-L.* Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines. J. Am. Chem. Soc. 2009, 131, 1366-1367.

19. Hou, G.-H.; Xie, J.-H.; Wang, L.-X.; Zhou, Q.-L.* Highly Efficient Rh(I)-Catalyzed Asymmetric Hydrogenation of Enamines Using Monodente Spiro Phosphonite Ligands. J. Am. Chem. Soc. 2006, 128, 11774-11775.