学术报告
题目：Searching for New Reactivity: Iron-Catalyzed Stereoselective Olefin Aminohydroxylation and Aminofluorination Reactions
主讲人：Prof. Dr. Hao Xu, Department of Chemistry, Georgia State University,
时间：2016年12月7日上午9:30-10:30
地点：化学楼二楼会议室
报告摘要：
Numerous pharmaceuticals contain at least one nitrogen atom and many of those nitrogen atoms are directly attached to stereogenic centers. Therefore, synthetic methods that incorporate selective nitrogen atom transfer to readily available hydrocarbons are important tools for the synthesis of these valuable molecules. While methods for selective olefin aziridination and direct C-H amination are well-established, methods for direct difunctionalization of olefins with a nitrogen atom and a range of heteroatom-based functional groups are less explored yet critically important to organic synthesis and its applications to the biomedical sciences. The lecture is about the discovery and development of a series of iron-catalyzed nitrogen atom transfer reactions with an emphasis on stereoselective olefin aminohydroxylation and aminofluorination reactions.
Dr. Hao Xu 现任乔治亚州立大学化学系副教授， 2001年在北京大学获得学士学位，2006年在 Scripps研究所(导师： K. C. Nicolaou) 获得博士学位，2006年至2010年在哈佛大学 Eric Jacobsen课题组从事博士后研究，2010年起进入乔治亚州立大学化学系独立建组开展研究工作。 Prof. Xu研究工作集中于基于氮原子转移的铁催化烯烃选择性双官能团化反应研究，已在Science、J. Am. Chem. Soc.、 Angew. Chem. Int. Ed.等国际著名学术期刊上发表学术论文20余篇。Prof. Xu曾获得多项荣誉如 Thieme Chemistry Journal Award (2014), National Science Foundation (NSF) CAREER Award (2014), Dean’s Early Career Award at Georgia State (2015), CAPA Biomatick Distinguished Junior Faculty Award (2015), and most recently Alfred P. Sloan Research Fellowship (2015).
Recent Publications：
1. “Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion” J. Am. Chem. Soc., 2016, 138, 11360.
2. “Iron-Catalyzed Direct Diazidation for a Broad Range of Olefins” Angew. Chem. Int. Ed., 2015, 55, 534.
3. “ Iron(II)-Catalyzed Intermolecular Amino-Oxygenation of Olefins through the N-O Bond Cleavage of Functionalized Hydroxylamines” J. Am. Chem. Soc., 2014, 136, 13186.
4. “Iron(II)-Catalyzed Intramolecular Aminohydroxylation of Olefins with Functionalized Hydroxylamines” J. Am. Chem. Soc., 2013, 135, 3343.
